Gemfibrozil

CAS NO:25812-30-0
Molecular formula:C15H22O3 
Molecular weight:250.333 g/mol
Gemfibrozil belongs to the class of medications known as fibrates. It is used to treat high cholesterol.Gemfibrozil is used in combination with a healthy diet and exercise to lower cholesterol levels in the blood. Reduction of cholesterol levels has been shown to reduce the risks associated with heart disease, such as heart attack.Gemfibrozil has been shown to inhibit peripheral lipolysis and to decrease hepatic extraction of free fatty acids, which, in turn, decreases hepatic triglyceride production. Gemfibrozil also inhibits the synthesis and increases the clearance of apolipoprotein B, a carrier molecule for VLDL.Gemfibrozil may also accelerate turnover and removal of cholesterol from the liver and increase excretion of cholesterol into the feces.Gemfibrozil has variable effects on LDL cholesterol.